| 摘要 |
Novel derivatives of 2-aminoethanol of the formula <IMAGE> in which Ar represents optionally substituted phenyl, m represents a number from 0 to 3, n represents the number 0 or 1, and alk represents alkylene having 2 to 5 carbon atoms, the nitrogen atom and the oxygen atom or, if n is 0, the phenyl radical, being separated from each other by at least two carbon atoms, and R1 and R2 each represents, independently of the other, hydrogen or lower alkyl, or together represent lower alkylene, oxa-lower alkylene, thia-lower alkylene, aza-lower alkylene or N-lower alkyl-aza-lower alkylene, with the proviso that, if m is 0, the phenyl radical Ar contains at least one substituent and a phenyl radical Ar that is substituted by one or two hydroxy groups or protected hydroxy groups contains at least one additional substituent which is different from those substituents, in the form of racemic mixtures, racemates, optical antipodes or salts thereof. Compounds of this kind act to some extent as blockers and to some extent as stimulators of beta -adrenergic receptors with more or less pronounced cardioselectivity and can accordingly be used, on the one hand, in the indications customary of beta -blockers and, on the other hand, for the treatment of insufficient heart output, asthma and circulatory disorders. |
