| 摘要 |
<p>NEW MATERIAL:Fortimicin derivatives of formula I (Z is amino group-protecting group; R1 is Z, COCH2NHZ; X is halogen). EXAMPLE:Tetra-N-benzyloxycarbonyl-2-chloro-2-deoxy-2-epifortimicin A. USE:Synthetic intermediate of antibiotic: the dehalogenation and removal of, protection readily give the compound of formula IV (R2 is H, COCH2NH2), an antibiotic. PREPARATION:A compound of formula II is halogenated with, e.g., CCl4-triphenylphosphine to give the compound of formula I. Triphenylphosphine dibromide or triphenylphosphine diiodide may be used as another halogenating agent.</p> |
