发明名称 |
ANALOGUES OF SOMATOSTATIN, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PREPARATION |
摘要 |
Polypeptides of the formula I wherein A is L- or D-Trp, X is H-(Aeg)m-Cys- or H-(Aeg)m-Ala-Gly-Cys-, Y is -Cys-(Aeg)n-OH or X and Y taken together are a 2-aminoethyl-glycyl group in the ring position and m and n are 0, 1, 2, 3 or 4, provided that m + n are at least 1, the cyclic disulfide derivatives, protamine zinc and protamine aluminum complexes and pharmaceutically acceptable acid addition salts thereof, having valuable pharmacological properties, and methods for the preparation thereof using conventional liquid or solid phase syntheses. |
申请公布号 |
DE2860623(D1) |
申请公布日期 |
1981.05.07 |
申请号 |
DE19782860623 |
申请日期 |
1978.10.05 |
申请人 |
F. HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT |
发明人 |
DAIRMAN, WALLACE MARK;FELIX, ARTHUR MARTIN;GALLO-TORRES, HUGO E.;HEIMER, EDGAR PHILIP;MEIENHOFER, JOHANNES ARNOLD |
分类号 |
C07K14/575;A61K38/00;A61K38/04;A61P1/04;C07K1/113;C07K14/655;(IPC1-7):07C103/52;61K37/02 |
主分类号 |
C07K14/575 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|