Antibiotic substances, a process for the preparation and compositions thereof; a new strain of Staphylococcus epidermidis which produces the said antibiotic substance and compositions thereof.

摘要

The invention relates to an antibiotic polypeptide compound, or addition salt thereof, caving a molecular weight no greater than 10000 and possessing bactericidal and bacteriolytic activities in respect of Gram-positive bacteria, the said compound comprising within the molecular structure thereof amino acid derivative units of formulae
-NH-R1-CO-, -NH-R2-CO- , -NH-R3-CO-,
-NH-R4-CO-, -NH-R5-CO-,- NH-R6-CO-,
-NH-R7-CO- and

wherein NH2-R1-COOH, NH2-R2-COOH, NH2-R3-COOH, NH2-R-COOH, NH2-R5-COOH, NH2-R6-COOH and NH2-R7-COOH respectively represent isoleucine, phenylalanine, alanine, aspartic acid, glutamic acid, lysine and glycine and

represents proline.
The invention further provides a process for the preparation of antibiotic polypeptides by the aerobic culturing of a strain of S. epidermidis.
The invention also provides compositions comprising antibiotic substances and methods of treatment therewith.
The invention further provides a new strain of Staphylococcus epidermidis which produces the antibiotic polypeptides, compositions containing the said strain and a method of cosmetic or prophylactic treatment of the human skin with such compositions.