NEW 7-ALKYL STEROID DERIVATIVES,PROCESS FOR THEIR PREPARATION,THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Novel 7-alkyl- DELTA 4-17 alpha -pregnene-3-ones of the formula I wherein R is selected from the group consisting of saturated and unsaturated alkyl of 2 to 8 carbon atoms, cycloalkyl alkyl of 4 to 8 carbon atoms and arylalkyl of 7 to 12 carbon atoms and X and Y form the group or X is OH and Y is and M is selected from the group consisting of hydrogen, alkali metal and NH4 and the wavy line indicates the alpha - or beta -position or mixtures thereof having aldosterone antagonistic activity and increased hydrosodium diuresis with organic potassium conservation while devoid of secondary hormonal effects and their preparation.