INTERMEDIATES FOR POLYCYCLIC QUINONOID ANTIBIOTICS

摘要

RC 3.0-126 INTERMEDIATES FOR POLYCYCLIC QUINONOID ANTIBIOTICS ANDREW S. KENDE YUH-GENG TSAY JOHN E. MILLS There is provided a novel method of synthesizing certain tetracyclic quinones. In particular, there is provided a novel route to the synthesis of (?)-7-deoxydauno-mycinone and analogs thereof, which includes the provision of novel tri- and tetracyclic quinone intermediates. The -7-deoxydaunomycinone derived from naturally occurring daunomycin is a known compound, which is itself an intermediate in the preparation of the clinically accepted anti-tumor antibiotics daunomycine and its derivative adriamycin.