发明名称 |
Processes for preparing 2-chloro-5-trifluoromethylpyridine |
摘要 |
One process comprises the step of reacting an amount of 5-carboxy-2-pyridone directly with both a suitable chlorinating agent and a suitable fluorinating agent to selectively transform both the 5-carboxy group and the 2-positioned oxygen function of the ring. A second process comprises the steps of reacting an amount of 5-carboxy-2-pyridone with a suitable fluorinating agent to selectively transform the 5-carboxy group without altering the 2-positioned oxygen function of the ring and reacting the 5-trifluoromethyl-2-pyridone thereby formed with a suitable chlorinating agent to cause 2-chloro-5-trifluoromethylpyridine to form. A third process comprises the steps of reacting an amount of a 5-carboxy-2-pyrone compound with a suitable fluorinating agent to selectively transform the 5-carboxy group without altering the 2-positioned oxygen function of the ring, reacting the 5-trifluoromethyl-2-pyrone compound thereby formed with an ammonia-containing agent in the presence of a caustic material to cause 5-trifluoromethyl-2-pyridone to form, and reacting the 5-trifluoromethyl-2-pyridone thereby formed with a suitable chlorinating agent to cause 2-chloro-5-trifluoromethylpyridine to form.
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申请公布号 |
US4249009(A) |
申请公布日期 |
1981.02.03 |
申请号 |
US19790007632 |
申请日期 |
1979.01.29 |
申请人 |
REILLY TAR & CHEMICAL CORP. |
发明人 |
BAILEY, THOMAS D. |
分类号 |
C07D213/64;(IPC1-7):C07D213/26 |
主分类号 |
C07D213/64 |
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