| 摘要 |
The present invention relates to a novel process for the preparation of 7 beta -amino-3- or -2-cephem-3-ol-4-carboxylic acid compound of the formula IA <IMAGE> or the formula IB <IMAGE> in which R@ denotes hydrogen or an amino protective group R@, R@ represents hydrogen or an acyl group Ac, or R@ and R@ together denote a bivalent amino protective group, R<2> represents hydroxyl or a radical R@ which together with the carbonyl group -C(=O)-, forms a protected carboxyl group, and R<3> represents hydrogen, lower alkyl or optionally substituted alpha -phenyl-lower-alkyl, characterised in that, in a compound of the formula <IMAGE> in which the double bond can be in the 2,3- or 3,4-position, the amino group -N(R@)(R@) is subjected to solvolysis to give the -OR3 group.
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