| 摘要 |
5-Substituted 2-pyrroleglyoxylic acids, L- and DI-5-substituted 2-pyrrolylglycines and their derivatives of the formulae <IMAGE> and pharmaceutically acceptable cationic and acid addition salts thereof, wherein R is hydrogen or alkyl having from one to four carbon atoms; R1 is alkyl or alkylthio having one to ten carbon atoms, alkenyl having from three to six carbon atoms, cycloalkylthio having from five to seven carbon atoms or AR3 where A is a member bonded to the pyrrole ring and is alkylene or alkylenethio having from one to four carbon atoms or alkenylene having from two to four carbon atoms and R3 is cycloalkyl having from three to seven carbon atoms, cycloalkenyl having from five to seven carbon atoms or C6H4R4 where R4 is H, F, Cl, Br, I, alkyl or alkoxy, the latter two groups each having from one to four carbon atoms; R2 is hydroxy, alkoxy having from one to four carbon atoms or amino; are useful in treatment of diseases and conditions which are characterized by reduced blood flow, reduced oxygen availability or reduced carbohydrate metabolism in the cardiovascular system.
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