PROCESS FOR THE PREPARATION OF N-SUBSTITUTED THIAZOLYL DERIVATIVES OF OXY-IMINO-SUBSTITUTED CEPHALOSPORINS

摘要

Derivatives of N-substituted thiazolyl oxy-imino-substituted cephalosporins, such as, for instance, the compound 7 beta -[2-(2-imino-3-hydroxy-4-thiazolinyl)-2-methoxy-imino-acetamino]-3-[(t etrazolo[1,5-b]pyridazin-6-yl)-thiomethyl]-3-cephem-4-carboxylic acid, are disclosed. The disclosed compounds have high anti-bacterial activity against Gram-positive and Gram-negative bacteria normally susceptible to cephalosporins.