| 摘要 |
About 67 title compds. (I; R1 = H; R2 = Br, Cl; R3 = F, CH3O, acetyl, CCl3 CN, carboethoxy; R4, R5, = H, Me, Et, Pr, Bu, t-Bu, cyclohexyl, benzyl) were prepd. by halogenation of II. Thus, 3 g 2-amino-N-cyclohexyl-5-fluoro-N-methyl-benzyl-amine in 300 mlo CH3COOH was reacted with 1098 g Br2 in 300ml CH3COOH to give 2-amino-N-bromocyclohexyl-5-fluoro-n-methyl-benzylamine. When 50 mg/kg and 100mg/kg of IHCI (R1 = H; R2 = Br; R3 = carbethoxy; R4, R5 = ethyl) was administered orally to female rats, the ulcer was decreased by 52%, 79%, resp.
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