发明名称 |
METHOD FOR THE PRODUCTION OF 6,7-DIMETHOXY-4-AMINO-2- (4-(2-FUROYL)-1-PIPERAZINYL) QUINAZOLINE HAVING AN ANTIHYPERTENSIVE EFFECT |
摘要 |
<p>A novel process is provided for the preparation of 6,7-dimethoxy-4-amino-24-(2-furoyl)-1-piperazinyl!quinazoline. It includes as a final step, cyclizing methyl-N-(3,4-dimethoxy-6-cyanophenyl)-4-(2-furoyl)-1-piperazinyl! thioformamidate by heating, together with ammonia, in a polar solvent, in the presence of an alkali metal amide. The methyl-N-(3,4-dimethoxy-6-cyanophenyl)-4-(2-furoyl)-1-piperazinyl!thio formamidate is preferably formed by reacting 3,4-dimethoxy-6-4-(2-furoyl)-1-piperazinyl-thiocarbamido!benzonitrile with methyl chloride. By this process the quinazoline ring in prazosine is produced within the molecule, rather than in a reaction between two different molecules.</p> |
申请公布号 |
CA1092117(A) |
申请公布日期 |
1980.12.23 |
申请号 |
CA19770293065 |
申请日期 |
1977.12.14 |
申请人 |
ORION-YHTYMAE OY, NILSIAENKATU 10-14, SF-00510, HELSINKI 51 |
发明人 |
HONKANEN, ERKKI J.;PIPPURI, AINO K. |
分类号 |
C07D405/12;A61K31/496;A61K31/517;C07C331/28;C07D307/68;C07D403/04;(IPC1-7):07D405/14 |
主分类号 |
C07D405/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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