摘要 |
<p>An aminopropanol compound of the formula <IMAGE> wherein R1 and R2 are individually selected from hydrogen and lower alkyl; or R1 and R2 together represent an alkylene radical; R3 is hydrogen or acyl; A is one of the following structures <IMAGE> wherein R4 is hydrogen or lower alkyl optionally substituted by hydroxyl halogen and lower alkylthio; and R5 and R6 are individually selected from lower alkyl; B is alkylamino which optionally carries a phenyl and a phenoxy radical optionally substituted by at at least one of halogen, hydroxyl or lower alkyl, lower acyl, lower alkylthio, acylamino, aminocarbonyl, lower alkoxy, lower alkenyloxy, phenoxy, lower alkenyl, lower alkylsulphonyl, lower alkylsulphinyl or haloalkyl; or B is an aryl- or heteroaryloxymethylpiperidine radical optionally substituted by at least one of halogen hydroxyl or lower alkyl, hydroxyl alkyl or carboxamido alkyl, or by lower alkoxy, lower acyl, amino, carboxamido, lower alkylcarbonylamido or lower alkylsulphonylamino; and the pharmacologically acceptable salts thereof, are outstandingly effective beta blockers and blood-pressure depressants.</p> |