发明名称 |
Potent inducers of terminal differentiation and method of use thereof |
摘要 |
The invention provides compounds, several of which belong to a class having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound. The invention also concents a method of selectively inducing termini differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effect to selectively induce terminal differentiation. Moreover, the invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells, thereby inhibiting their proliferation and suppressing oncogenicity. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound in an amount effective less than an amount which would cause toxicity in the patient.
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申请公布号 |
US5608108(A) |
申请公布日期 |
1997.03.04 |
申请号 |
US19950424556 |
申请日期 |
1995.04.17 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;THE TRUSTEES OF COLUMBIA UNIVERISTY IN THE CITY OF NEW YORK |
发明人 |
MARKS, PAUL A.;RIFKIND, RICHARD A.;BRESLOW, RONALD;JURSIC, BRANKO |
分类号 |
C07C233/05;C07C233/07;C07C233/36;C07C235/74;C07C243/28;C07C259/06;C07C259/08;C07C259/10;C07D231/32;C07D231/36;C07D239/60;C07D239/62;C07D243/08;(IPC1-7):C07C259/06;A61K31/19 |
主分类号 |
C07C233/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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