发明名称 |
D,L-2-Amino-4-(2-aminoethoxy)-trans-but-3-enoic acid derivatives |
摘要 |
The amino acid 2-amino-4-(2-aminoethoxy)-trans-but-3-enoic acid can be conveniently prepared via novel intermediates from a 2,2'-disubstituted diethyl ether and a dialkyl N-protected amidomalonate starting material using a multi-step process. Preferred starting materials are bis-2-chloroethyl ether and diethyl acetamidomalonate. The process, in a preferred embodiment, proceeds through the key intermediate ethyl-2-acetamido-4-[2-(2-phthalimido)ethoxy]-but-2-enoate.
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申请公布号 |
US4238622(A) |
申请公布日期 |
1980.12.09 |
申请号 |
US19770824371 |
申请日期 |
1977.08.15 |
申请人 |
HOFFMANN-LA ROCHE INC |
发明人 |
KEITH, DENNIS D;WEIGELE, MANFRED |
分类号 |
C07D209/48;(IPC1-7):C07C101/28 |
主分类号 |
C07D209/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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