| 摘要 |
<p>Described is a transdermal therapeutic system for administering physostigmin through the skin, the system comprising a back film which is impermeable to the active substance, an adhesive reservoir layer containing 40 to 90 percent by wt. of polymer material and 0.1 to 20 percent by wt. of physostigmin base or one of its pharmaceutically acceptable salts, plus a detachable protective film covering the reservoir layer. The reservoir layer contains acrylate and/or methacrylate polymer material plus 0.1 to 40 percent by wt. of a plasticizer containing hydroxyl groups and having an HLB value between 1.1 and 12.0, with the exception of compounds causing physostigmin disintegration such as methanol, ethanol, isopropanol, propanediol or glycerol. There is also described a process for the production of this system.</p> |
