7-Methyl and 7-methyl-8-lower alkyl B/C cis or trans morphinan-6-one compounds, process for their preparation and pharmaceutical preparations containing them.

摘要

Disclosed are 7-methyl and 7-methyl-8- lower alkyl substituted B/C Cis or Trans morphinan-6-one compounds characterized by the structural formula: <CHEM> Specific compounds, included within the scope of the foregoing general formula wherein R1 is H or methyl, R2 is cyclopropylmethyl or cyclobutylmethyl and R3 is H, methyl or ethyl are useful as mixed analgesics/narcotic antagonists.