NITROGENOUS HETEROCYCLIC COMPOUND AND MEDICINAL USE THEREOF

摘要

A compound represented by the general formula (I): (I) (wherein the symbols are the same as defined in the description), a salt thereof, an N-oxide form or solvate of either, or a prodrug of any of these. The compound represented by the general formula (I) has CXCR4 antagonistic activity. It is hence useful as, e.g., a preventive and/or therapeutic agent for CXCR4-mediated diseases such as inflammatory/immunologic diseases (e.g., articular rheumatism, arthritis, retinopathy, pulmonary fibrosis, and rejection reactions of transplanted organs), allergic diseases, infectious diseases (e.g., human immunodeficiency virus infection and acquired immunologic deficiency syndrome), psychoneurotic diseases, cerebral diseases, cardiac/vascular diseases, metabolic diseases, cancer diseases (e.g., cancer and cancer metastasis) or as a drug for regenerative medical.