| 摘要 |
7-(2-Aminothiazolyl-2-imino-acetamido)-3-heterocyclyl-thiomethyl-- 3-cephem-4-carboxylic acid derivs. of formula (I) and their salts and intermediates (III)' are new. (where R1 = opt. protected amino, R2 = aliphatic hydrocarbyl opt. substd. by one or more acceptable gps. R3 = opt. protected carboxy and R4 = a five-membered nitrogen-contg.heteromonocyclic gp. having one or more lower alkenyl gp(s). With the condition that R2 is not = methyl when R4 = lower alkenyl substd.tetrazolyl. In cpd. (III)', R2' = cyclopentyl or 3,4-dichlorobenzyl).(I) have high activity against both Gram-positive and Gram-negative bacteria which may be administered orally parenterally or locally in
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