发明名称 |
ANALOGIFORFARANDE FOR FRAMSTELLNING AV 2-AMINO-4HYDROXI-7,7-DIMETYL-7,8-DIHYDROPTERIDIN-6-KARBOXALDEHYD |
摘要 |
Title compds are formula (I), where R' and R2 are 1-4C alkyl or CR1R2 is a 4-6 membered spiralkyl gp., and are prepd. e.g. by (a) mild oxidation (O2 and I2/H+) of the corresp. 6-hydroxymethyl deriv. or (b) reductive cyclisation of a 2-amino 4-(1,1'-dialkyl-3'-hydroxyacetonyl )amino 6-hydroxy 5-nitro-pyrimidine oxime. (I) inhibits hydroxymethyldihydropteridine pyrophosphokinase, and compsns. with dihydrofolate reductase inhibitors and/or p-aminobenzoic acid competitors are synergistic. |
申请公布号 |
SE415563(B) |
申请公布日期 |
1980.10.13 |
申请号 |
SE19740001254 |
申请日期 |
1974.01.31 |
申请人 |
* THE WELLCOME FOUNDATION LTD |
发明人 |
H C S * WOOD;N * WHITTAKER;I * STIRLING;K * OHTA |
分类号 |
A61K31/505;A61K31/63;C07D475/04;(IPC1-7):07D475/04 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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