发明名称 |
Method of magnetic separation of cells and the like, and microspheres for use therein. |
摘要 |
Magneticaly-responsive microspheres having Protein A associated with the outer surfaces thereof are reacted with antibodies selective to the cells, bacteria, or viruses to be separated from a mixed population to attach the antibodies in oriented relation with their Fab arms extending outwardly, and the microspheres are then used in a magnetic separation procedure. The preferred microspheres are prepared from a mixture of albumin, Protein A, and magnetic particles, the microspheres being prepared so that the Protein A is present in the exterior surfaces for antibody binding. |
申请公布号 |
EP0016552(A1) |
申请公布日期 |
1980.10.01 |
申请号 |
EP19800300546 |
申请日期 |
1980.02.25 |
申请人 |
NORTHWESTERN UNIVERSITY |
发明人 |
WIDDER, KENNETH, JON;SENYEI, ANDREW ERWIN |
分类号 |
G01V3/08;A61K35/12;C12N1/02;C12N7/02;G01N27/72;G01N33/543;G01N33/544;G01N33/553 |
主分类号 |
G01V3/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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