摘要 |
<p>Physiologically-acceptable substituted 1,2-ethylene-diamines and 1,3-propylenediamines, in free-base and in acidaddition-salt form, have highly pronounced and cardioselective .beta.-adrenolytic action, antiarrhythmic action and hypotensive action on administration to humans. The diamines are, more specifically, N-¢3-aryloxy-2-hydroxypropyl!-N'-¢1,3-(di-R3)-2,4-dioxypyrimid-6-yl! (ethyle?e or propylene)diamines wherein R3 is -H or lower alkyl and the aryl nucleus is either further unsubstituted, further monosubstituted or further disubstituted. The compounds are prepared e.g., by reacting a corresponding N-¢3-phenoxy-2-hydroxypropyl! (ethylene or propylene)diamine with a corresponding 6-chloropyridine-2,4-dione in a suitable medium containing an acid-binding agent. Such compounds are administered orally or parenterally in effective, but substantially non-toxic, doses either in substantially pure form, in virtually any standard dosage form or in combination with one or more other pharamacologically- and chemically-compatible drugs.</p> |