| 摘要 |
NEW MATERIAL:A pyrimidine derivative of formula I (R<1>,<2> are H, (substituted) alkyl, phenyl, heterocyclic group, cycloalkyl, etc.). EXAMPLE:5H-5-Oxo-6-carbamoylthiazolo[3,2-a]pyrimidine. USE:Antiphlogistic agent, antipyretic agent, blood platelet coagulation inhibiting agent, immuno-regulating agent, etc. Synthetic intermediate of various pharmacologically active substances. PROCESS:The compound of formula I is prepared, e.g. by reacting an acid halide or mixed acid anhydride of a compound II with an amine III in a solvent such as ether, THF, etc., optionally in the presence of a base, or by reacting the compound II with the compound III in the presence of a condensing agent. |
