| 摘要 |
NEW MATERIAL:The title compound of formula I {R<1> is formula II (R<5> is H, halogen, nitro, OH, alkoxy group, etc.; R<6> is OH, alkoxy, acyloxy group, etc.), formula III (R<7> is amino, OH, alkyl group, etc.), formula IV [R<8> is alkyl group; R<9> is (protected) imino, or oxo group]; R<2> is alkyl group; R<3> is (protected) carboxy group; R<4> is acyloxymethyl group, etc.}. EXAMPLE:7-[ 2-Methoxyimino-2-( 2-amino-1,3-thiazol-4-yl )acetamide ]cephalosporanic acid (syn-isomer). USE:Antibacterials having greater activities than the anti-isomer. PROCESS:A compound of formula V or its reactive derivative at the amino group or their salt is reacted with a substituted acetic acid of formula VI to give the compound of formula I. |
