PRODUCTION OF N-SUBSTITUTED 2-CARBAMOYL PHOSPHINIC ACIDS

摘要

PRODUCTION OF N-SUBSTITUTED 2-CARBAMOYL PHOSPHINIC ACIDS. Production of N-substituted 2-carbamoyl phosphinic acids of the general formula: (I) in which R1 stands for an alkyl group having 1 to 4 carbon atoms or an aryl group; R2 and R3 stand independently of each other for an alkyl group having 1 to 4 carbon atoms, an aryl group- or a hydrogen atom; R4 stands for an alkyl group having 1 to 18 carbon atoms, an aryl group or a hydrogen atom; and R5 stands for an alkyl group having 1 to 18 carbon atoms or an aryl group. More specifically, a 2-chloroformyl phosphinic acid chloride of the general formula (II) is reacted at 120 to 170.degree.C with an amine of the general formula (III) and resulting N-substituted 2-carbamoyl phosphinic acid chloride of the general formula (IV) the latter compound being obtained while hydrogen chloride is split off, is hydrolyzed with water.