发明名称 Thiaprostaglandins
摘要 13-Thiaprostanoic acid derivatives of the formula <IMAGE> wherein A is -CO- or -CHOH-, B is -CH2-CH2- or -CH=CH- R1 is H or alkyl of 1 to 4 carbon atoms, m is a whole number from 0 to 5, n is a whole number from 0 to 3 or, when B is -CH=CH-, additionally 4, 5, 6, 7, 8 or 9, R2 is alkoxy of 1 to 4 carbon atoms, phenoxy, pyridyl, thienyl, naphthyl, phenyl substituted by F, Cl, Br, OH, OCH3 or OF3 or phenoxy substituted by F, Cl, Br, OH, OCH3, CH3 or CF3 or, when B is -CH=CH-, additionally hydrogen, phenyl or tolyl, R3 is H, methyl or ethyl, possess pharmacological activity, including blood pressure lowering activity.
申请公布号 US4210651(A) 申请公布日期 1980.07.01
申请号 US19780870555 申请日期 1978.01.18
申请人 MERCK PATENT GMBH 发明人 BAUMGARTH, MANFRED;KRAMER, JOSEF;ORTH, DIETER;RADUNZ, HANS-ECKART
分类号 C07D333/34;A61K31/557;A61K31/5575;A61P43/00;C07C;C07C67/00;C07C401/00;C07C405/00;C07D213/32;(IPC1-7):A61K31/19;A61K31/21;C07C177/00 主分类号 C07D333/34
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