| 摘要 |
<p>Treatment of renal calculus comprises administering a (co)polymer (I) derived from an olefinically unsatd. mono- or polycarboxylic acid (II). If (I) is water-soluble, it has mol. wt. >10000, and if it forms colloidal aq. solns. it has swelling index >=10 (pref. 10-500). Unit dose compsns. contain 0.1-20 g of (I), opt. in slat form. Pref. (II) include acrylic, (m)ethacrylic, alpha-chloroacrylic, +-cyanoacrylic, crotonic, beta-acryloxypropionic, hydrosorbic, sorbic, alpha-chlorosorbic, cinnamic, beta-styrylacrylic, hydromuconic, itaconic, citraconic, mesaconic, muconic, glutaconic and aconitic acids. (I) dissolve calculi and bond calcium so that it is excreted in faeces rather than urine. They are effective in treatment of urolithiasis in lower doses than phosphates, and are easily dosed since they can be administered in liquid form. Daily dose is pref. 10-400 mg/kg p.o.</p> |
