| 摘要 |
The subject 8-amino-6-methoxy lepidine derivatives have the formula: <IMAGE> wherein, R represents an -alkylene (tertiary) amine, -alkylene-NH2, [(N-alkylsubstituted piperadyl amino)-alkylene-, -alkylene-(tertiary) amine or -alkylene-N-heterocyclic; R1, represents an alkoxy, alkyl, halogenated alkyl, alkenyl, aryloxy, halogen or hydrogen radical; R2 represents an alkyl, halogenated alkyl or aryloxy; n represents integers 3, 4, 5, 6 or 7; and pharmaceutically acceptable salts thereof wherein the salt forming acid or acid-hydrate is organic or inorganic. These derivatives afford improvement in means for the chemotherapy of leishmaniasis. Presence of a basic sidechain attachment at position 8- provides means for enhancement of the effectiveness of such compounds, which may be administered parenterally or orally to infected animals.
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