4-[2-(2-Substituted phenyl)ethenyl]-N-alkenyl or alkinyl substituted 1,2,3,6-tetrahydropyridines

摘要

Compounds of the formula and their pharmaceutically acceptable acid addition salts <IMAGE> wherein X is lower alkoxy, Cl, Br, or F; R is <IMAGE> or -C 3BOND C-R4; R1, R2, R3, and R4 are independently selected from hydrogen and methyl; n is an integer from 1 to 3 provided that when n is 3 at least two of R1, R2 and R3 are hydrogen and R4 is hydrogen, and further provided that when n is 2 at least one of R1, R2 and R3 is hydrogen; are disclosed. These compounds possess useful pharmaceutical activities due to their ability to inhibit the prostaglandin-inactivating enzyme 15- alpha -hydroxyprostaglandin dehydrogenase.