| 摘要 |
<p>The present invention provides a process for the manufacture of 5-amino-1,2,3-thiadiazole of the formula I (I) , wherein a halogen-acetaldehyde of the general formula II X - CH2 - CH = O (II) , in which X represents a halogen atom, or an acetal thereof is reacted with a hydrazine derivative of the general formula III H2N - NH - COR (III), in which R represents an alkoxy group, an amino group or an alkylamino group, to form an acyl-hydrazone of the general formula IV X - CH2 - CH = N - NH - CO - R (IV) , in which X and R have the meanings given above, the acylhydrazone is then reacted with thionyl chloride of the formula V SOCl2 (V) to form a 5-halogeno-1,2,3-thiadiazole of the general formula VI (VI) , in which X has the meaning given above, and the 5-halogeno-1,2,3-thiadiazole is then reacted with ammonia. The process permits the problem-free manufacture of 5-amino-1,2,3-thiadiazole in only a few stages and in greater yields and which is suitable for the industrial production of this substance.</p> |
