发明名称 |
PROCESS FOR THE PRODUCTION OF 9-('-D-ARABINOFURANOSYL) ADENINE, 5'-PHOSPHATE |
摘要 |
<p>Process for the production of an ester product, 9-(.beta.-D-arabinofuranosyl)adenine, 5'-phosphate, in which the mixture resulting from reaction of 9-(.beta.-D-arabino-furanosyl)adenine with phosphorylating agent in trialkyl phosphate solvent is subjected to aqueous hydrolysis, the pH of the hydrolysis mixture is adjusted upward sufficiently to cause separation into aqueous and non-aqueous liquid phases, the trialkyl phosphate solvent is removed, and the product is precipitated from the residual aqueous mixture and isolated.</p> |
申请公布号 |
CA1077030(A) |
申请公布日期 |
1980.05.06 |
申请号 |
CA19770290047 |
申请日期 |
1977.11.02 |
申请人 |
PARKE, DAVIS & COMPANY |
发明人 |
BEHNKE, WALTER E.;MARSH, WILLIAM R.;HASKELL, THEODORE H. |
分类号 |
C07H19/20;(IPC1-7):07H19/20 |
主分类号 |
C07H19/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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