发明名称 |
FREMGANGSMAATE FOR FREMSTILLING AV ET ANTIHEMOFILIFAKTORPREPARAT FRA MENNESKEBLODPLASMA |
摘要 |
An antihemophilic factor preparation (AHF) of high solubility and long half-life is produced in high yields by complete or partial thawing of deep-frozen human blood plasma by irradiation with electromagnetic waves of a frequency of about 108-1015 for a period of time and with an energy penetration such that the temperature in the thawed plasma does not exceed 10 DEG C. at any point, and processing in a manner known per se by centrifuging the thawed product to form a cryoprecipitate, redissolving the cryoprecipitate in a buffer and isolating a concentrated solution which, if desired, is freeze-dried. Irradiation is preferably effected by microwaves of a frequency of 108-3x1011 Hz, in particular 2x109-3x1010 Hz, or by infrared light, said frozen plasma being preheated if desired. The preparation is suitable for injection performed by the patient himself without medical assistance. |
申请公布号 |
NO793501(A) |
申请公布日期 |
1980.05.05 |
申请号 |
NO19790003501 |
申请日期 |
1979.10.31 |
申请人 |
NORDISK INSULINLABORATORIUM, |
发明人 |
RASMUSSEN, MIRELLA EZBAN,;JENSEN, JOERGEN VIKELSOEE,;HANSEN, JOERGEN FREDERIK, |
分类号 |
C07K14/745;A61K35/14;A61K38/00;A61K38/16;C07K14/435;C07K14/755;H01R13/52;(IPC1-7):61K/ |
主分类号 |
C07K14/745 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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