PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE ANTHRACYCLINONES

摘要

Optically active anthracyclinones are prepared by reacting an optically active (-) 1,4-dimethoxy-6-hydroxy-6-acetyl-tetralin of formula II: (II) with a phthalic anhydride of formula IV: (IV) wherein:a) R1 is hydrogen and R2 and R3 are the same and are both hydrogen or methyl, methoxy, chlorine ox bromine;b) R2 and R3 are both hydrogen and R1 is methyl, methoxy, chlorine or bromine;c) R1 and R3 are both hydrogen and R2 is methoxy; in the presence of AlCl3 or AlBr3 and an alkali metal chloride at 130-180.degree.C for 1 to 10 minutes.