发明名称 |
2'-Deoxy-5-fluorouridine derivatives, a process for producing the same and antitumor agents comprising the same. |
摘要 |
<p>Novel 2 min -deoxy-5- fluorouridine derivatives represented by the formula;
<CHEM>
wherein R represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an acetyloxy group or a halogen atom, and n is an a integer in the range of 1 to 3 are provided. These have good antitumor activities and low toxicities and are suitable for use as antitumor agents. The new compounds may be prepared by reacting 2 min -deoxy-3 min ,5 min -di-0-acetyl-5- fluorouridine with a benzoyl halide of the formula;
<CHEM>
where hal is a halogen atom and R and n are as before, preferably in the presence of an organic base, particularly triethylamine and a solvent, particularly dioxane. </p> |
申请公布号 |
EP0009882(A1) |
申请公布日期 |
1980.04.16 |
申请号 |
EP19790301782 |
申请日期 |
1979.08.31 |
申请人 |
FUNAI PHARMACEUTICAL IND., LTD. |
发明人 |
FUJII, SETSURO;SAKAKIBARA, EUCHI |
分类号 |
C07H19/073;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7072;A61P35/00;C07H19/06;(IPC1-7):07H19/08;61K31/70 |
主分类号 |
C07H19/073 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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