Enzyme derivatives for use in the treatment of venous thrombosis, compositions containing them and their preparation.

摘要

A pharmaceutical composition which comprises a pharmaceutically acceptable carrier together with an in vivo fibrinolytic enzyme as defined herein wherein the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis at a rate such that the pseudo-first order rate constant for hydrolysis is in the range 10-6 sec-1 to 10-3 sec-1 in isotonic aqueous media at pH 7.4 at 37 DEG C.; is useful in the treatment of venous thrombosis.