Antiinflammatory 4,5-diaryl-2-nitroimidazoles, method for their preparation and pharmaceutical composition containing them.

摘要

The new compounds of the formula …… where… R1 and R2 independently are …… with the proviso at least one of R1 and R2 must be …… Y1 is F, Cl N(CH3)2 or C1-C4 alkoxy;… Y2 is H, F, Cl;… R3 is H, …… 2-tetrahydropyranyl, 2-tetrahydrofuranyl, …… R6 is C1-C3 alkyl, benzyl, -CH2CH2OCH3 or …… R7 is C1-C4 alkyl or benzyl; and Ar is …… where… Y3 is H, F, Cl, Br, C1-C4 alkyl, C1-C4 alkoxy or nitro;… e.g. 4,5-bis(4-fluorophenyl)-2-nitroimidazole; or their pharmaceutical suitable salts have antiinflammatory activity. A method for preparation of these compounds, involving nitration of 4,5-disubstituted-1-(substituted) imidazoles in 2-position, is given.