| 摘要 |
<p>A series of compounds showing high antileukemic activity against P388 murine leukemia and increased aqueous solubility due to substitution of -0H for the known -NH2 at the 3" position of the hexopyranose sugar, i.e., daunosamine. These compounds are coupled products of aglycon selected from desmthoxy daunomycinone, adriamycinone, and carminomycinone. These compounds are coupled at the 0-7 position of the aglycon with an (Alpha)-L-lyxo hexopyranose sugar, which sugar isomer particularly sustains or potentiates the biological activity of the coupled compound as well as ameliorates the dose related cardiotoxicity of the parent and known compounds set out below: </p> |
