| 摘要 |
Prodn. of immunoglobulin (IG) soln. for intravenous application comprises slurrying a salt-contg. (IG) soln. with aq. wet, amorphous, chamically-pure silicic acid (I) of submicroscopic size distribution so as to purify the suspension by adsorption. Mixt. is adjusted to pH 6.8 (at 20 degrees C), incubated with stirring for 30-60 min at about 20 degrees C, then (I) removed and the whole procedure repeated at pH 6.5(at 20 degrees C). Pref. as many purificn. stages are carried out as needed to reduce the content of substances with anticomplement activity to the desired level, and the amt. of (I) used is given by the equations CP:Cs = 1:Z = Cp (g/dl): m damp SiO2(g)X100/Vp(ml). damp SiO2(g) = Z.Cp.Vp/100. (C,m,V are not defined; subscripts p and s refer to protein and suspension). Solns. are used in passive immunoprophylaxis of lagammaglobulinaemia and other antibody deficiency conditions, and of infections diseases. These highly purified solns. have few or no side effects, good antibacterial, antiviral and antitoxin activities, and acceptable residence time in the organism. |
