| 摘要 |
1. A stable liquid formulation containing 2,6-diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidine (trimethoprim) and a sulfonamide of the formula I see diagramm : EP0009559,P6,F1 in which R is 6-chloro-2-pyrazinyl or 6-chloro-3-pyridazinyl, or a salt thereof, in the quantity ratio of 1 : 1 to 1 : 20, preferably 1 : 4 to 1 : 5, with a total proportion of 15 to 25 per cent by weight being dissolved in a physiologically compatible, watermiscible solvent, a solubility-promoting agent and a surfactant, and a base in the case where the sulfonamide is not used as a salt, in which composition the solvent used is N-methylpyrrolidone, the surfactant used is bis-(2-ethylhexyl)-Na-sulfosuccinate or poly-oxyethylene-sorbitan monolaurate (polysorbatum 20), the solubility-promoting agent used is hydroxyethyltheophylline or polyvinylpyrrolidone K 25, and the base used is ethenolamine. |
