| 摘要 |
A compound of the formula:
<CHEM>
wherein R<1> is amino or protected amino,
R<2> is lower alkyl substituted with a substituent selected from the groups consisting of cyano, carbamoyl, hydroxy, protected hydroxy, amino, protected amino, lower alkoxy, lower alkylthio, lower alkenylthio, aryl which may have one or more suitable substituent(s), and heterocyclic group which may have one or more suitable substituent(s),
R<3> is carboxy or functionally modified carboxy, and
R<4> is hydrogen or halogen
and its pharmaceutically acceptable salt and pharmaceutically acceptable bioprecursor thereof and process for their preparation.
<??>The invention also relates to a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient, and to a method for treating an infectious disease caused by pathogenes, which comprises administering the above compound to infected human being or animals.
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