发明名称 |
Fused substituted aminopyrrolidine derivative |
摘要 |
A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.
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申请公布号 |
US2013029977(A9) |
申请公布日期 |
2013.01.31 |
申请号 |
US20090459612 |
申请日期 |
2009.07.02 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED;TAKAHASHI HISASHI;KOMORIYA SATOSHI;KITAMURA TAKAHIRO;ODAGIRI TAKASHI;INAGAKI HIROAKI;TSUDA TOSHIFUMI;NAKAYAMA KIYOSHI;TAKEMURA MAKOTO;YOSHIDA KENICHI;MIYAUCHI RIE;NAGAMOCHI MASATOSHI |
发明人 |
TAKAHASHI HISASHI;KOMORIYA SATOSHI;KITAMURA TAKAHIRO;ODAGIRI TAKASHI;INAGAKI HIROAKI;TSUDA TOSHIFUMI;NAKAYAMA KIYOSHI;TAKEMURA MAKOTO;YOSHIDA KENICHI;MIYAUCHI RIE;NAGAMOCHI MASATOSHI |
分类号 |
A61K31/4709;A61K31/5383;A61P1/02;A61P1/12;A61P11/00;A61P11/08;A61P13/02;A61P13/08;A61P15/00;A61P17/00;A61P17/10;A61P27/02;A61P29/00;A61P31/00;A61P31/04;A61P31/06;A61P31/08;A61P33/00;A61P37/00;C07D401/10;C07D498/06 |
主分类号 |
A61K31/4709 |
代理机构 |
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代理人 |
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