| 摘要 |
<p>Compounds of the general formula:- <IMAGE> wherein Y represents <IMAGE> (in which R<4> represents H or a hydroxy- protecting group which is eliminated under basic conditions), Z represents <IMAGE> (in which R<5> represents H or a tetrahydropyran- 2-yl group), R<1> represents a formyl group, or a group of the formula -CH2OR<4>, R<2> represents a single bond, or a C1-5 alkylene group R<3> represents H, a C1-8 alkyl or C1-8 alkoxy group, or a C4-7 cycloakyl or C4-7 cycloalkyloxy group unsubstituted or substituted by at least one C1-8 alkyl group, or represents a phenyl or phenoxy group unsubstituted or substituted by at least one halogen atom, trifluoromethyl group or C1-4 alkyl group, with the proviso that, when R<2> represents a single bond, R<3> does not represent an alkoxy, cycloalkyloxy or phenoxy group, THP represents a tetrahydropyran-2-yl group, and the double bond between the carbon atoms in positions 13 and 14 is trans, with the provisos that, (i) when Z represents <IMAGE> (in which R<5> represents H), Y represents <IMAGE> (in which R<4> represents a hydroxy- protecting group) and R<1> represents a group of the formula -CH2OR<4> (in which R<4> represents a hydroxy-protecting group), and (ii) when Y represents <IMAGE> R<1> represents a formyl group, are useful as intermediates in the synthesis of therapeutically useful prostaglandin analogues.</p> |
