Method for testing to predict and/or diagnose allergy to penicillins, and compounds and compositions for use in such tests

摘要

The invention relates to the testing of humans or other animals, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicilloyl-polylysine (PPL) preparations, new materials for use in minor determinant mixture (MDM) compositions and novel test methods employing such materials. The new PPL preparations comprise homogeneous, high purity, maximally coupled, alpha -diastereoisomeric, penicilloyl conjugates of low molecular weight PPLs. The PPL materials of the invention have the molecular structure in accordance with the following generic formula: wherein: R is selected from the group consisting of H