| 摘要 |
<p>Thienylamines of formula (I) and their pharmaceutically acceptable salts and intermediates of formula (II) are new. In the formulae, R1 is H or 1-4C alkyl; R'1 is 1-4C alkyl; R2 and R3 are each 1-4C alkyl or NR2R3 is a satd. heterocycle opt. contg. a further O,S or N heteroatom, this N opt. being substd. by 1-6C alkyl, phenyl-lower alkyl or phenyl, the phenyl gps. opt. being substd. by >=1 halogen, 1-6C alkyl, 1-6C alkoxy or CF3 gp(s); and X is H or halogen, esp. Cl or Br. (I) are analgesics and antiinflammatories for use in human or veterinary medicine. Toxicity is low, e.g. LD50 is >350 mg/kg p.o. (mouse). Doses are pref. 0.025-0.750 g/day.</p> |
