PREPARATION OF DIALKALI METAL HEXAHYDROPYRIMIDINE-1, ACETATE AND DIALKALIMETAL 5-HYDROXYHEXAHYDROPYRIMIDINE-1, 3-DIACETATE

摘要

PREPARATION OF DIALKALI METAL HEXAHYDROPYRIMIDINE-1,3-DIACETATE AND, DIALKALIMETAL 5-HYDROXYHEXAHYDROPYRIMIDINE-1,3-DIACETATE or, (in which M is an alkali metal ion) is prepared by forming an alkaline aqueous solution of an alkali metal hydroxide and hexahydropyrimidine or 5-hydroxyhexahydropyrimidine and feeding an alkali metal cyanide and aqueous formaldehyde into the alkaline aqueous solution while agitating the resulting reacting mixture and while maintaining its temperature within a range effective for vaporizing byproduct ammonia therefrom, the alkali metal cyanide and the formaldehyde being fed at rates effective for maintaining an excess of unreacted cyanide over unreacted formaldehyde in the reacting mixture. The alkali metal cyanide can be replaced with HCN and an amount of the alkali metal hydroxide about stoichiometrically equivalent to the HCN.