发明名称 |
CEFALOSPORIN-ANTIBIOTIKA. |
摘要 |
Cephalosporin antibiotics of general formula: <IMAGE> (I) (wherein Ra and Rb, which may be the same or different, each represent a C1-4 alkyl group or Ra and Rb together with the carbon atom to which they are attached form a C3-7 cycloalkylidene group, and Y(+) represents a C-linked 5- or 6-membered heterocyclic ring containing at least one C1-4 alkyl-substituted quaternary nitrogen atom, which ring may also contain one or more sulphur atoms) exhibit broad spectrum antibiotic activity, the activity being unusually high against gram-negative organisms such as strains of Pseudomonas organisms. A particular antibiotic compound of formula (I) possessing excellent antibacterial activity against strains of Pseudomonas organisms, as well as other valuable therapeutic properties, is (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxycyclobut-1-oxyimino )acetamido]-3-[(1-methylpyridinium-4-yl)-thiomethyl]ceph-3-em-4-carbox ylate. The invention also includes the non-toxic salts and non-toxic metabolically labile esters of compounds of formula (I). Also described are compositions containing the antibiotics of the invention and processes for the preparation of the antibiotics. |
申请公布号 |
NO791730(A) |
申请公布日期 |
1979.11.27 |
申请号 |
NO19790001730 |
申请日期 |
1979.05.25 |
申请人 |
GLAXO GROUP LTD, |
发明人 |
O`CALLAGHAN, CYNTHIA HILDA,;AYRES, BARRY EDWARD,;LIVERMORE, DAVID GEORGE HUBERT,;NEWALL, CHRISTOPHER EARLE,;WEIR, NIALL GALBRAITH, |
分类号 |
A61K31/545;A61K31/546;A61P31/04;C07D277/20;C07D501/24;C07D501/36 |
主分类号 |
A61K31/545 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|