| 摘要 |
1,3,5(10)-8 alpha -oestratrienes of the following formula <IMAGE> in which R<1> is acyl and R<2> is lower alkyl are prepared. These compounds are obtained by oxidising a corresponding 3-hydroxy-13-R<2>-8 alpha -oestra-1,3,5(10)-trien-17-one with lead tetraacylate and rearranging the reaction product in the presence of a strong acid. The corresponding 1,3-hydroxy compounds are likewise prepared from the 1,3-diacyl compounds and can be converted into the corresponding diethers. The reduction of 17-keto compounds I into corresponding 17ss-hydroxy compounds is also described. The conversion of the said 17-keto compounds into 17ss-hydroxy-17 alpha R<4> compounds by reacting the 17-keto compounds with an organometallic compound which supplies the radical R<4>, which is a saturated or unsaturated, optionally substituted hydrocarbon group, is also described. The said compounds display favourable oestrogenic dissociation and can be used for the treatment of manifestations of oestrogen deficiency.
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