BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES

摘要

PROBLEM TO BE SOLVED: To provide methods for treating obesity and diabetes.SOLUTION: The invention provides a treatment method for solving the problems of the following a)-h) and the like by contacting a distal ileum of individuals in need the following a)-h) and the like with an apical sodium-dependent bile acid transporter inhibitor represented by formula (I). a) Reducing food intake; b) Inducing satiety; c) Reducing blood and/or plasma glucose levels; d) Treating a metabolic disorder; e) Reducing the body weight; f) Stimulating L-cells in the distal gastrointestinal tract; g) Increasing the concentration of bile acids and salts thereof in the vicinity of L-cells in the distal gastrointestinal tract; and h) Enhancing enteroendocrine peptide secretion.SELECTED DRAWING: Figure 1