ANTI-TUMOR PRODUCT FROM CLOSTRIDIUM PERFRINGENS

摘要

Wild strain Lechien of the organism Clostridium perfringens is attenuated with nitrosoguanidine. To produce an anti-tumor preparation, the attenuated organism is grown first on a growth medium then on a sporulation medium and the resulting growth recovered as a bacillary suspension, a spore suspension, or culture filtrates. The preparation in any of these forms has the property of inhibiting the growth of Ehrlich's solid tumor, of reducing the tumor size, and lengthening the survival time of the host.