| 摘要 |
Demethylgentamycin derivative, compd. I (R1 = R2 = H) was prepd. by reacting compd. I'(R1, R2 = methyl), compd. I"(R1 = methyl, R2 = H) or compd. I"'(R1 = H, R2 = methyl) with oxidant e.g., iodine, bromine, chlorine, or permaganate in inert solvent for 0.5-50hr at -20≦̸C-100≦̸C. Title compd. exhibited antibacterial activity against gram pos. and neg. bacteria with low toxicity.
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